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At week 12, patients receiving long-acting risperidone 25 mg and 50 mg had improved significantly in five of the eight domains of the SF-36 (bodily pain, general health, social functioning, role-emotional, and mental health) compared with patients receiving placebo.
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Consequently, the clinical effect of the drug (i.
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ALT elevation, 18% at 6 months, and 2 stopped drug for ALT elevations of 3 times “basal level”).
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Off-label uses include treatment of other symptoms of autistic disorder, including aggression, self-injurious behavior, hyperactivity, and inattention.
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Embodiment 9 before and after being stored for 6 months, which indicates that in vivo drug release behavior of the risperidone microspheres in Embodiment 9 after being stored for 6 months does not change substantially and the quality of the risperidone microspheres according to an embodiment of the present disclosure is much more stable.
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The above effects showed little or no reversibility in females after a 12 week drug-free recovery period.
Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder.
Oral versus depot antipsychotic drugs for schizophrenia--a critical systematic review and meta-analysis of randomised long-term trials".
Therefore, Risperidone is not expected to substantially inhibit the clearance of drugs that are metabolized by this enzymatic pathway.
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